Common long-term effects include alignment problems and or eventual spinal degeneration at T1 and L2 with right-sided symptoms in the upper back shoulder, and lower back area due to progressive disk dehydration, along with general osteoarthritic changes in various joints due to cartilage dehydration and calcium depletion. As a result, Vitamin B6 therapy should only be used for someone with an otherwise difficult-to-manage low magnesium high calcium ratio... Full Text